Endocrine Abstracts

Introduction: Type 2 diabetes results from insulin resistance and B-cell failure. Bariatric surgery is an effective therapeutic modality for type 2 diabetes. Indeed, it induces high remission rates through improved insulin sensitivity and secretion. While the critical role of skeletal muscle in glucose homeostasis has long been known, its role as an endocrine organ secreting peptides, called myokines, has recently been identified. Some of these myokines were shown to influence...

Introduction: Sarcoidosis is a systemic disease of unknown aetiology, characterized by non-caseified granulomatous reaction that can involve multiple organs. The disease typically presents with pulmonary infiltrates, bilateral hilar and mediastinal lymphadenopathy and uveitis, but may also less frequently affect other organs, including the hypothalamic-pituitary axis. Malignancy rates in sarcoidosis patients have been reported as 1 to 2%1,2, chronic inflammation bei...

Objective: Melatonin is a hormone secreted by the pineal gland which modulates sleep and wakefulness rhythms. Decreased melatonin secretion has been shown to be associated with increased daytime sleepiness and disturbed circadian rhythm in (irradiated) survivors of childhood craniopharyngeoma. The present study was performed to explore possible relationships between disturbed sleep, psychosocial impairment and melatonin secretion in patients treated with cranial radiotherapy a...

Objective: Brain tumour treatment with radio- and chemotherapy may lead to endocrine and other medical sequelae. Still, many countries lack tailored surveillance programs for such patients so that potential health problems may remain unrecognized. The present study was performed to investigate endocrine and psychosocial impairment in a single centre university setting in Germany in patients treated with cranial radiotherapy as a part of brain tumour or leukaemia treatment....

Introduction: In Belgium, 21.4% of patients hospitalized with COVID-19 are diabetic1. In this study, we describe the characteristics of diabetic patients hospitalized for COVID-19 in a Belgian tertiary care center.Patients and methods: The Clinics Ethics Committee approved the systematic registration of anonymized data from hospitalized patients with confirmed COVID-19 (N° CEHF 2020/22MAI/290), i.e. a positive SARS-CoV-2 PCR test on nasop...

Background and aims: The contribution of myokines to improved glucose homeostasis induced by bariatric surgery is unknown. Our study aims to identify myokines potentially improving glucose homeostasis following bariatric surgery.Patients and methods: Obese insulin-resistant patients were evaluated before and 3 months after bariatric surgery, i.e. a sleeve gastrectomy or a Roux-en-Y gastric bypass (n62). Muscle biopsies were taken from vastus lat...

Purpose: Our study aims to identify myokines potentially involved in improved glucose homeostasis after bariatric surgery.Methods: Obese patients were evaluated before and 3 months after bariatric surgery. Insulin resistance was assessed using the Homeostasis Model Assessment (HOMA) test. Muscle biopsies were taken from vastus lateralis. Genes encoding myokines involved in glucose homeostasis were identified using RNA-sequencing. Changes in myokines expr...